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Our research in Nutritional Science

Our nutrition practice is evidence based and our team keeps up-to-date with the latest in nutritional science.  This means you get the best advice and recommendations to support your health.

Our team, led by our Scientific Director Ciara Wright PhD, have a number of projects and collaborations underway, including several recent publications in medical and science journals.  Listen to her podcast about her research and publications here

Fertility and pregnancy

Sperm health and DNA Fragmentation

Modifiable factors to help DNA fragmentation

Sperm DNA Fragmentation: modifiable clinical, lifestyle and nutritional factors in male infertility – read the open access paper here

Published 2014 in Reproductive BioMedicine Online

Sperm DNA Fragmentation can be present in men with an abnormal semen analysis but is also present in one of out four men with a normal semen analysis and is known to have a negative impact on male fertility.  A major cause is oxidative stress – damage caused in the body by inflammation, physical issues with the testes, heat, smoking, certain chemicals, being overweight and poor diet.

  • Recommendations are made to include a diet rich in antioxidants, such as zinc, selenium, vitamin C and E. These are found in fruit, vegetables, nuts and seeds
  • Analysis of previous clinical trials was carried out to determine the best use of supplements and whether they are useful and safe
  • Recommendations are made for doctors, fertility consultants, healthcare providers and patients to test levels first before over-supplementing as this can also cause harm.

Lifestyle Factors and Sperm Health

Book title – “Male and Sperm Factors that Maximize IVF Success” published by Cambridge University Press

Published April 2020,  book available for purchase here

 

Nutrition has a major impact on male fertility and can change parameters such as morphology, motility and sperm count.

  • The current scientific literature was analysed for evidence on how diet affects male fertility
  • A fertility friendly diet is advised which is high in fruits, vegetables, fish, pulses, nuts, seeds and wholegrains. A fertility friendly diet is low in red meat, sugar and processed foods.
  • Moderate exercise is beneficial where disrupted sleep or shift work may have a negative effect

Supplements in Pregnancy

 PregnancySafety and Efficacy of Supplements in Pregnancy in collaboration with Ben Brown ND – read the open access paper here

Published in Nutrition Reviews, October 2020 – highly regarded nutrition journal

 

 

 

 

  • To provide evidence based recommendations for women, healthcare practitioners and doctors
  • A wide range of vitamins and minerals are examined giving the advantages and disadvantages to supplementing in pregnancy, including safety for mother and child
  • Doses are examined to provide accurate and safe recommendations for pregnant women

Nutrients in Pregnancy

Importance of magnesium in pregnancy

  The importance of magnesium in pregnancy – read the open access paper here

Published in Nutrition Reviews, September 2016

 

 

Magnesium deficiency is prevalent in women of childbearing age. The need for magnesium increases during pregnancy, and the majority of pregnant women likely do not meet this increased need. Magnesium deficiency or insufficiency during pregnancy may pose a health risk for both the mother and the newborn, with implications that may extend into adulthood of the offspring.  This review provides recommendations for further study and improved testing using measurement of red cell magnesium. Pregnant women should be counseled to increase their intake of magnesium-rich foods such as nuts, seeds, beans, and leafy greens and/or to supplement with magnesium at a safe level.

Nutrition to support Assisted Conception

Presentations at International Medical Conference – Upper Egypt Assisted Reproductive Conference                   

Dr Ciara Wright presented at an international medical conference in Egypt February 2017.  The conference covered medical updates and the latest research in assisted reproduction.  Ciara was the only Irish speaker and  only nutritionist to speak as part of 150 international delegates with 1800 attendees and gave 2 presentations:

Modifiable Nutritional and Lifestyle Factors in Sperm DNA Fragmentation

Strategies to Reduce Overweight in IVF 

Thyroid conditions

Iodine and thyroid health

iodine status and thyroid healthAssessing iodine status in front line healthcare – read the open access paper here

Published in the Journal of Clinical Nutrition and Diet Care, November 2018

 

  • Iodine is critical in the production of thyroid hormones
  • Iodine deficiency is widespread and may contribute to high incidence of thyroid conditions
  • Measuring iodine can be difficult
  • Recommendations are made for doctors and healthcare providers on how to measure iodine more accurately
  • An example case study shows how restoring an iodine deficiency improved thyroid function (hypothyroid) in a patient and completely restored symptoms of fatigue, weight gain, constipation and muscle pain

 

Nutritional support for thyroid health

Dr Ciara Wright presented to the British Association of Nutrition Therapy (BANT) in 2020 on Thryoid and whole body health.  In collaboration with Benjamin Brown ND, this review will examine the evidence around nutrients and foods to support thyroid health.

Expected submission date: 2022

 

 

 

 

Digestion

IBS and SIBO

Eradication of Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome using herbal therapy; a case study  

In collaboration with Melissa Dooley from Gastrolife

Status:  Provisionally accepted for publication in International Journal of Functional Nutrition.

Publication:  Dec 2021

 

  • SIBO causing severe food intolerances and digestive discomfort
  • Accurate measurement of SIBO in the gut by breath test
  • Eradication of SIBO using herbal supplements and a low FODMAP diet
  • Analysis of before and after symptoms using a validated symptom questionnaire
  • To provide evidence to show eradication of SIBO and improvement of symptoms following our protocol

Obesity and Non-Alcoholic Fatty Liver Disease

In collaboration with:

 

 

 

Development and initial validation of a short food frequency questionnaire for assessing dietary intakes of non-alcoholic fatty liver disease patients.

Published in Proceedings of Nutrition Society 2018      Full text available here

Collaborators: Professor Suzanne Norris, Hepatologist, Dr Sara Naimimohasses, St James Hospital and Department of Clinical Medicine, Trinity College Dublin, Carla Bredin MSc, Assoc Prof Bernadette Moore, University of Leeds, Dr Kathryn Hart, University of Surrey

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in the developed world and is associated with obesity and increased intakes of sugar and saturated fat.  The only treatment for NAFLD is dietary intervention focusing on weight loss, fat loss and a reduction in saturated fat and sugar in the diet.

 

 

 

Development and relative validation of a short food frequency questionnaire for assessing dietary intakes of non-alcoholic fatty liver disease patients

Published in European Journal of Nutrition March 2020     Full text available here

Collaborators: Professor Suzanne Norris, Hepatologist, Dr Sara Naimimohasses, St James Hospital and Department of Clinical Medicine, Trinity College Dublin, Carla Bredin MSc DipNT, Assoc Prof Bernadette Moore, University of Leeds, Dr Kathryn Hart, University of Surrey, Neil Hancock, School of Food Science and Nutrition, University of Leeds

 

Patients attending the hepatology department in St James’s Hospital, Dublin were requested to participate in food diary analysis. No such analysis had ever been performed on an Irish population.

  • Determined dietary pattern that is high risk for NAFLD in Ireland as high fat, high sugar, high processed foods
  • Development of a shorter questionnaire (food frequency questionnaire) was achieved to allow for faster analysis of patient’s food intake
  • This questionnaire was proven to be accurate and therefore ‘validated’ by comparing to gold standard

 

A 12-week multi-component dietary intervention improves markers of non-alcoholic fatty liver disease in Irish patients in tertiary care.

Published in the Proceedings of the Nutrition Society 2020   Full text available here

Collaborators: Professor Suzanne Norris, Hepatologist, Dr Sara Naimimohasses, St James Hospital and Department of Clinical Medicine, Trinity College Dublin, Deirdre NiFhloinn DipNT, Assoc Prof Bernadette Moore, University of Leeds, Stephen Finn, Consultant Histopathologist St James Hospital, Dr Kathryn Hart, University of Surrey

We undertook a 12 week pilot study in the hepatology department of St. James’ Hospital Dublin.  Groups were separated into control (no intervention), dietary intervention (12 week course) and exercise intervention. The dietary intervention was led by Dr Ciara Wright.

  • Participants on the 12 week healthy eating course lost body fat and weight
  • Participants commented on increased knowledge and understanding around food
  • Participants increased intake of fruits, vegetables, oily fish and reduced saturated fat, refined carbohydrates and sugars
  • Participants improved liver scores and markers of liver health

 

 

Differential effects of dietary versus exercise intervention on intrahepatic MAIT cells and histological features of NAFLD

Submitted for publication November 2021

Collaborators: Professor Suzanne Norris, Hepatologist, Dr Sara Naimimohasses, St James Hospital and Department of Clinical Medicine, Trinity College Dublin, Deirdre NiFhloinn DipNT, Assoc Prof Bernadette Moore, University of Leeds, Stephen Finn, Consultant Histopathologist St James Hospital,  Dean Holden and  Niall Conlon, Department of Immunology, St. James’s Hospital, Ann Monaghan, Megan Kennedy, John Gormley and Philip O’Gorman Department of Physiotherapy, Trinity College Dublin , Peter Beddy Department of Radiology, St. James’s Hospital, Jacinta O’Sullivan and Margaret Dunne Trinity Translational Medicine Institute, Trinity College.

Mucosal associated invariant T (MAIT) cells promote inflammation in obesity and chronic liver disease, and are implicated in the progression of non-alcoholic fatty liver disease (NAFLD).

Liver histology, clinical parameters, and MAIT cell populations were assessed at baseline and following completion of a 12-week dietary intervention or exercise intervention, and in control group. The dietary intervention was led by Dr Ciara Wright.

 

Dietary patterns in Irish patients with non-alcoholic fatty liver disease: a cross sectional study

Abstract presented at European Association for the Study of the Liver November 2017

 

New dietary tool to assess nutritional deficiencies in a NAFLD populatioon: a simple tool for primary care

Poster in American Association for the Study of Liver Diseases in San Fransisco, Nov 2018

 

 

 

Development and Initial Validation of a Short Food Frequency Questionnaire for Assessing Dietary Intakes of Non-alcoholic Fatty Liver Disease Patients

Presented at Nutrition Society Meeting in Leeds 2018

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    Testimonials

    I just wanted to let you know that we had a beautiful baby. Please pass on our sincere thanks, we really appreciate it and obviously the fantastic result we achieved! Thanks to you for your very efficient and kind care during this time.A happy couple from Dublin
    Thank you so much for all your help and support. We cannot believe our little miracle is here, I feel like we have won the lotto! I definitely think it was all the changes we made, she is a product of good nutrition!Anon, Carlow
    I want to thank you for helping us both this year. Not only has my colitis settled down and I feel much better, you were also a huge part in helping us achieve our ultimate goal of getting pregnant. We will both be eternally grateful for this and thank you sincerely. D&GS, Galway
    Compared to my last test 8 months ago the morphology increased from 3% to 35% and my DNA Fragmentation went from 37% to 22%. I could only have achieved these results with your assistance and expertise and would like to thank you for all the guidanceEP, Limerick
    Thankfully we dramatically improved the quality of my eggs and were left with one viable embryo which went on to be a successful pregnancy! We are over the moon and thrilled with our little girl. I just wanted to send you an update to let you know and perhaps to give hope to others in a similar position and unsure about whether to try the nutritional approachSinead, Dublin
    I feel so alive and energised. The added bonuses are a healthy BMI, normal cholesterol levels, 20kgs lighter and a reduction to my metabolic age by 20 years+. It has been so worth all the time and effort to create this new healthy lifestyle. Thank you for all your excellent advice and encouragement. Your professionalism and attention to detail has brought me to this transformed new state, a new me!Maria, Dublin
    Since my first appointment the improvement in my health is amazing. Symptoms of my Inflammatory Bowel Disease have decreased and my energy levels have increased. My hair has become more conditioned and my nails are less brittle. I can honestly recommend a visit to Glenville Nutrition Clinic for a particular illness or as a boost to your general wellbeing E.K, Galway
    I FINALLY I lost all the extra pounds I was holding for two years, and my digestion improved MASSIVELY!! Nothing compared to when I first came looking for help!! I WILL ALWAYS BE SO THANKFUL FOR THAT, you wouldn't believe how much good you did for me, I was lost. Fitness Instructor, Dublin
    My journey with Glenville Nutrition has made a vast improvement in my health and well-being. You’ve helped me to adopt a completely new approach to food and healthy eating. To date I have lost 26 lbs. In just 7 weeks my cholesterol dropped from 5.8 to 4.4. My arthritic joints have vastly improved and I look forward to my daily walk. Friends and family have complimented me on how well I look!! Again my sincere thanks & appreciation of your excellent blend of professionalism, encouragement and compassion. Kathleen, Galway
    I had expected the physical benefits, but the mental and emotional benefits were unexpected and glorious. I cannot recommend Glenville Nutrition highly enough. I think it is fair to say that working with them changed my life. Sometimes you don’t even realise how bad you feel until you start to feel better. That is a gift that you can give yourself. Sincerest thanks for all you did for me.Aisling, Kilkenny
    I am so thrilled with having met you at Glenville Nutrition. The advice and supplements I have received is helping me enormously. I am feeling 1000 times better since I first started.Patient, Dublin
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    How to eat green

    Sustainable eating can be both healthy and good value.  Read our top tips for eating green

    How to thrive in the menopause and beyond

    Dr Marilyn Glenville shares how to successfully manage your menopause symptoms, while boosting your energy, improving your health, and feeling more alive than you’ve felt in years! Details here

    Nutrition for male and female fertility

    Learn key dietary approaches and essential nutrients for both male and female fertility here or watch Heather in action on Virgin Media

    Could digestive enzymes help you?

    For some of our patients, digestive enzymes play an important role in reducing ongoing symptoms of bloating or reflux.  Ciara explains more here

    Immune health for fertility

    Trying to conceive?  Ciara Wright was recently interviewed by Ben Brown on immune health and personalised nutrition for fertility.  Listen in here and contact us for more information

    Click picture to download our 4 week nutrition plan for fertility with Sims IVF

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