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Advanced Immune Profile

Blood testImmune balance in pregnancy

During a pregnancy, the woman has to carry a foetus that is only half of her DNA (or not even if donor eggs are used in assisted conception).  The foetus is not recognised by her immune system as safe but still, a healthy pregnancy will allow the foetus to thrive and grow.  This is called tolerance.  The ways in which the human body adapts for foetal tolerance are the subject of much research and are truly fascinating.

However, much like in an autoimmune condition, sometimes the messaging is wrong.  If the immune system is out of balance or in a heightened sense of alertness this may cause the woman to fight off a pregnancy or implanting embryo.  This may result in infertility or miscarriage.  In some cases, we will hear from patients that everything seems fine with all their other tests, but they have never once had a positive pregnancy test.

Type of immune cells in pregnancy and fertility

The immune system is extremely complex but (very) simply put, you have two main arms of the immune system, namely Th1 and Th2.  The Th1 side is a more aggressive side that reacts to foreign invaders of non-self where the Th2 side is more involved with allergies. During a healthy pregnancy, we would like to tip the balance in favour of the Th2 side, which is one reason why women often find they have allergies such as hayfever for the first time when they are pregnant.  Women with autoimmune conditions will also often see a period of remission during pregnancy as their immune system calms.

We also have cells called Natural Killer cells or NK cells.  These are critical for immune defences also but have found to be raised in women with infertility or recurrent miscarriage. Much debate stems from the relevance of this association.  It is argued that the immune environment within the uterus is completely different to the immune system that is represented in a blood sample.  It is true that a certain level of NK cells are helpful for conception but it can also be argued that too many indicates an immune imbalance.

Understanding the exact immune imbalance present is an important first step.  We have recently launched comprehensive immune testing via our clinic.

The Advanced Immune Profile – Our advantage: Some lab tests measure cell types including including NK cells, Th1 and Th2 balance, CD4:CD8 ratio amongst many others.  Others, such as the ‘Chicago bloods’, analyses NK cell activity and your cytokine ratios, that is, the functionality or activity of immune cells.  We have chosen to use a lab test that does both.  Our Advanced Immune Profile measures a wide range of cell types, plus extra cytokines, NK cell numbers, NK cell type and NK cell activity.  We are therefore very happy to provide this highly informative test to our patients. Once we know what the immune picture is like, we can begin to change it and increase your chances of a healthy pregnancy.

Medicinal mushrooms

Medicinal mushrooms have powerful immune modulating effects.  There is much research into this exciting new field and now there are a large number of mushroom supplement products on the market.  We use MycoNutri under the training of Dr Trevor Wing in the UK and Dr Martin Powell.  It is not recommended to use medicinal mushrooms without having your immune profile tested first.  Mushrooms have different effects and it is important to know what cell types you are trying to affect before choosing the correct protocol.  In our experience, no two profiles are the same in our patients. It might mean that a combination of mushrooms and nutritional supplements is best or that you should outright avoid some types in order to prevent the imbalance from getting worse.

 

Who should take this test?  Women who are trying to conceive with any of the following:

  • ‘Unexplained infertility’
  • Failed IVF or ICSI cycles
  • Recurrent miscarriage
  • Miscarriage following IVF transfer of a good quality embryo
  • Women with autoimmune conditions or other inflammatory conditions that are trying to conceive

 

If you are interested in advanced immune testing: please contact us at clinic@glenvillenutrition.ie or make an enquiry online.

 

Dr Lyuda Shkrobot , Immune Fertility Specialist’ says.. ‘I have worked with a large number of patients who have tried unsuccessfully for years.  Once we balance their immune system, their chances of conceiving and staying pregnant increases significantly.’

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    Testimonials

    I just wanted to let you know that we had a beautiful baby. Please pass on our sincere thanks, we really appreciate it and obviously the fantastic result we achieved! Thanks to you for your very efficient and kind care during this time.A happy couple from Dublin
    Thank you so much for all your help and support. We cannot believe our little miracle is here, I feel like we have won the lotto! I definitely think it was all the changes we made, she is a product of good nutrition!Anon, Carlow
    I want to thank you for helping us both this year. Not only has my colitis settled down and I feel much better, you were also a huge part in helping us achieve our ultimate goal of getting pregnant. We will both be eternally grateful for this and thank you sincerely. D&GS, Galway
    Compared to my last test 8 months ago the morphology increased from 3% to 35% and my DNA Fragmentation went from 37% to 22%. I could only have achieved these results with your assistance and expertise and would like to thank you for all the guidanceEP, Limerick
    Thankfully we dramatically improved the quality of my eggs and were left with one viable embryo which went on to be a successful pregnancy! We are over the moon and thrilled with our little girl. I just wanted to send you an update to let you know and perhaps to give hope to others in a similar position and unsure about whether to try the nutritional approachSinead, Dublin
    I feel so alive and energised. The added bonuses are a healthy BMI, normal cholesterol levels, 20kgs lighter and a reduction to my metabolic age by 20 years+. It has been so worth all the time and effort to create this new healthy lifestyle. Thank you for all your excellent advice and encouragement. Your professionalism and attention to detail has brought me to this transformed new state, a new me!Maria, Dublin
    Since my first appointment the improvement in my health is amazing. Symptoms of my Inflammatory Bowel Disease have decreased and my energy levels have increased. My hair has become more conditioned and my nails are less brittle. I can honestly recommend a visit to Glenville Nutrition Clinic for a particular illness or as a boost to your general wellbeing E.K, Galway
    I FINALLY I lost all the extra pounds I was holding for two years, and my digestion improved MASSIVELY!! Nothing compared to when I first came looking for help!! I WILL ALWAYS BE SO THANKFUL FOR THAT, you wouldn't believe how much good you did for me, I was lost. Fitness Instructor, Dublin
    My journey with Glenville Nutrition has made a vast improvement in my health and well-being. You’ve helped me to adopt a completely new approach to food and healthy eating. To date I have lost 26 lbs. In just 7 weeks my cholesterol dropped from 5.8 to 4.4. My arthritic joints have vastly improved and I look forward to my daily walk. Friends and family have complimented me on how well I look!! Again my sincere thanks & appreciation of your excellent blend of professionalism, encouragement and compassion. Kathleen, Galway
    I had expected the physical benefits, but the mental and emotional benefits were unexpected and glorious. I cannot recommend Glenville Nutrition highly enough. I think it is fair to say that working with them changed my life. Sometimes you don’t even realise how bad you feel until you start to feel better. That is a gift that you can give yourself. Sincerest thanks for all you did for me.Aisling, Kilkenny
    I am so thrilled with having met you at Glenville Nutrition. The advice and supplements I have received is helping me enormously. I am feeling 1000 times better since I first started.Patient, Dublin
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